Do Antidepressants Help with Alcohol Withdrawal?

Robert Gerchalk

Robert is our health care professional reviewer of this website. He worked for many years in mental health and substance abuse facilities in Florida, as well as in home health (medical and psychiatric), and took care of people with medical and addictions problems at The Johns Hopkins Hospital in Baltimore. He has a nursing and business/technology degrees from The Johns Hopkins University.

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Can Antidepressants Help With Alcoholism?

If you or someone you care about is struggling with alcoholism, help is available. Many people who battle alcoholism also face a variety of mental health issues, such as depression. This is why a lot of doctors will prescribe antidepressants as part of a treatment plan. Antidepressants are also known to help alleviate some withdrawal symptoms. 

What Are Antidepressants?

Medications known as antidepressants help clients with the symptoms of depression and other mental health issues. Their mechanism of action involves modulating brain chemicals called neurotransmitters with a focus on norepinephrine and serotonin. Antidepressants work by influencing these substances, which in turn improves mood, reduces emotional suffering, and brings the mind back into balance for those with depressive illnesses. Due to the fact that various antidepressants have various therapeutic and adverse effect profiles, clinicians can choose the best antidepressant for their clients by taking into account their unique characteristics.

Sertraline (Zoloft)

Sertraline, commonly known as Zoloft, is a selective serotonin reuptake inhibitor (SSRI) prescribed to treat various mental health disorders, including depression, anxiety, and obsessive-compulsive disorder. It works by increasing serotonin levels in the brain, a neurotransmitter associated with mood regulation. By inhibiting serotonin reuptake, Zoloft enhances the availability of this neurotransmitter, helping to alleviate symptoms and restore a more stable emotional state in individuals with these conditions.

Fluoxetine (Prozac)

Fluoxetine, marketed as Prozac, is an SSRI used to treat depression, anxiety, and other mood disorders. Like Sertraline, Fluoxetine operates by increasing serotonin levels in the brain. Prozac inhibits the reuptake of serotonin, allowing for its prolonged action in nerve synapses. This mechanism helps alleviate symptoms of depression and maintain a more balanced emotional state in individuals with various mental health conditions.

Escitalopram (Lexapro)

Escitalopram, marketed as Lexapro, is another antidepressant belonging to the SSRI class. Lexapro treats depression and anxiety by increasing serotonin levels in the brain. Unlike Zoloft and Prozac, Lexapro primarily contains the S-enantiomer of citalopram, potentially resulting in a more refined and targeted action. The specific differences in side effects and efficacy tend to vary among individuals, guiding clinicians in selecting the most suitable medication based on a client’s profile.

Venlafaxine (Effexor)

Effexor, whose generic name is venlafaxine, is a serotonin-norepinephrine reuptake inhibitor that treats anxiety and depression. It affects the regulation of mood by increasing brain levels of norepinephrine and serotonin. Effexor changes the levels of both neurotransmitters, unlike Lexapro, Zoloft, and Prozac.

Is Alcohol a Depressant?

Alcohol has different impacts on different people’s moods. Although it may help with stress in the short term, it tends to have detrimental consequences for your mental health in the long run. Drinking alcohol on a regular basis raises the chance of developing mood disorders and worsens existing mental health issues. It has a depressive effect on the central nervous system after first producing a stimulating effect by inhibiting inhibitory brain activities. This causes drowsiness, impaired inhibitions, and a slowing of cognitive and motor functioning.

How Does Alcohol Affect Antidepressants?

Alcohol and medications do not mix well. Because of their shared effects on the central nervous system, the two medications can magnify each other’s negative effects. When taken with alcohol, antidepressants have a greater sedative effect, making the user even more sleepy and less coordinated than before. On top of that, drinking can negate the positive effects of antidepressants, making it more difficult to overcome anxiety and depression. Also worth noting is that if individuals drink in excess, it can cause their mental health to deteriorate quickly. Because suggestions may differ depending on the particular medicine and individual health considerations, it is essential to talk to a healthcare provider before drinking alcohol while taking antidepressants.

How Do Antidepressants Affect Alcohol?

Antidepressants affect the use of alcohol in several ways. While the specific interactions depend on the type of antidepressant, combining them with alcohol can exacerbate the sedative effects, increasing drowsiness and impairing coordination. Antidepressants can also alter how alcohol is metabolized in the body, potentially intensifying the impact of alcohol on the central nervous system. Concurrent use may compromise mental alertness and judgment. Additionally, the combination can affect liver function. It’s essential to consult healthcare professionals about potential interactions. Many doctors advise limiting or abstaining from alcohol when taking antidepressants for treatment. 

What Happens During Alcohol Withdrawal?

Withdrawal symptoms from alcohol differ from one person to the next, depending on a number of reasons. The exact symptoms, their severity, and how long they last depend on individuals’ drinking habits, how long they’ve been drinking, and their general health. Hereditary susceptibilities can play a role as well.

Whether users choose to suddenly stop or gradually decrease their drinking will impact the severity of their withdrawal symptoms. Other factors that impact the whole experience include social support, the availability of medical treatment, and the existence of preexisting mental health conditions. Due to the potentially fatal consequences of withdrawal symptoms, such as delirium tremens, individuals should seek the advice of a medical expert on how to appropriately manage their symptoms.

Anxiety

Heightened anxiety during alcohol withdrawal is common due to the impact of alcohol on the central nervous system. Chronic alcohol use alters neurotransmitter levels, particularly reducing gamma-aminobutyric acid (GABA), a calming neurotransmitter. Once a person stops drinking, GABA levels plummet, leading to increased neural excitability and heightened anxiety. The brain’s attempt to regain equilibrium greatly contributes to the withdrawal symptoms. Anxiety can be a prominent manifestation, underscoring the complex interplay between alcohol’s sedative effects and the brain’s adaptive response. This can make withdrawal a challenging and often anxiety-inducing process.

Tremors and Shaking

Tremors and shaking during alcohol withdrawal are primarily attributed to the sudden absence of alcohol’s suppressive effects on the central nervous system. Chronic alcohol use hampers the brain’s normal function, affecting neurotransmitters like GABA. When alcohol intake ceases, GABA levels drop, causing increased neural excitability and tremors. These physical manifestations are part of the body’s response to the abrupt shift in neurotransmitter balance. 

Hypertension

Hypertension during alcohol withdrawal stems from the intricate interplay between chronic alcohol use and the cardiovascular system. Prolonged alcohol consumption can lead to increased sympathetic nervous system activity and changes in blood vessel responsiveness. When alcohol intake suddenly ceases, the sympathetic nervous system remains hyperactive, causing elevated blood pressure. This heightened cardiovascular response is part of the body’s adjustment to the withdrawal of alcohol’s depressive effects. Monitoring blood pressure during alcohol withdrawal is crucial to address potential complications and ensure a safe transition to sobriety.

Hallucinations

Delirium tremens is a severe kind of hallucination that sometimes occurs in those going through alcohol withdrawal. This occurs because the use of alcohol on a regular basis upsets the equilibrium of neurotransmitters like glutamate and GABA. The changing amounts of neurotransmitters can then cause the overexcitation of brain circuits, which may contribute to hallucinations when alcohol use suddenly ceases. These visual distortions highlight the complicated neurochemical changes and increased neuronal activity that are hallmarks of acute alcohol withdrawal.

Insomnia

Alcohol’s direct effect on GABA levels raises neuronal excitability, which impacts the circadian cycle of the body. As a result, many people going through alcohol withdrawal experience sleep problems. Although extreme fatigue can accompany alcohol withdrawal, the changes in GABA levels can make it difficult to fall and stay asleep, leading to prolonged periods of insomnia. And unfortunately, a lack of sleep can further complicate other withdrawal symptoms, including anxiety, hypertension, and hallucinations. 

What Is Alcohol Treatment Like?

Alcohol treatment usually involves several stages. The first stage is detox, which involves physically withdrawing from the substance while under medical supervision. It’s also during detox that a person will go through multiple assessments so that healthcare professionals can determine the best type of treatment to recommend. For those with chronic alcohol use disorders, inpatient treatment usually works best. Inpatient programs range in length from 30 to 180 days or longer. 

If you can’t commit to an inpatient program, you can receive treatment through an outpatient center. Many facilities also offer intensive outpatient programs, allowing you to receive intense therapy for your substance use disorder while still residing at home. Outpatient programs work exceptionally well for those who have obligations at home or work that they need to attend to while also addressing their alcoholism. Outpatient programs last anywhere from a few weeks to several years. 

No matter the type of treatment that a person receives for alcoholism, aftercare plays an essential role in the recovery process. Aftercare services come in many forms, including one-on-one counseling, group therapy sessions, sober living homes, support groups, and more. 

Why Do Doctors Prescribe Antidepressants to Alcoholics?

Doctors may prescribe antidepressants to individuals with alcohol use disorders for various reasons. Alcohol dependence often coexists with mood disorders like depression or anxiety. Antidepressants can help manage these co-occurring conditions, improving overall mental well-being. Additionally, some antidepressants mitigate alcohol cravings or reduce the risk of relapse. These medications work on neurotransmitter imbalances in the brain, addressing both the emotional and physiological aspects of alcohol dependence. However, prescription decisions are highly individualized, and healthcare professionals must always carefully consider each client’s unique circumstances before incorporating antidepressants into a comprehensive treatment plan.

Are There Other Medications That Help With Alcohol Withdrawal?

Medications play a crucial role in managing alcohol withdrawal symptoms. Medical supervision is vital so that the medical staff can tailor medication regimens to each client’s needs, ensuring a safe and effective withdrawal process. Any medications that a doctor prescribes are part of a comprehensive approach that will likely include counseling, support groups, and ongoing treatment to foster a lasting recovery from alcohol use disorder.

Benzodiazepines, such as diazepam or lorazepam, help ease anxiety, insomnia, and seizures by calming the central nervous system. Antipsychotics like haloperidol can address severe agitation. Anti-seizure medications, including carbamazepine or valproic acid, can prevent or manage seizures. Medications for nausea, like ondansetron, alleviate gastrointestinal symptoms.

Using Dual-Diagnosis Treatment to Treat Alcoholism and Depression

To improve general health and promote long-term recovery, dual-diagnosis therapy takes into account the complex relationship between drinking and depression. Integrated treatments, which include interventions for depression and alcohol misuse, are beneficial for those dealing with both disorders. Most treatment plans include an assortment of psychotherapy, counseling, and support groups designed to treat both conditions at once. Medically assisted treatment plans allow clients to combine medications with other treatment approaches to treat their alcoholism and depression simultaneously. 

Are you ready to find the help you need to overcome depression and alcoholism? Alcohol Awareness connects people just like you with treatment providers across the country. We understand the complicated relationship between substance use disorders and other mental health disorders. Our number one goal is to connect people with the help they need to live a happy, sober life.